Successful fundraising led by Pembroke VCT and Downing Healthcare Ventures 

Proceeds will enable the Company to rapidly scale-up the commercial roll-out of its 3D AI surgical maps  product and continue to advance its plans to create value across its innovative cloud-based technology  platform 

Andrew Wolfson and Dr Nigel Pitchford appointed as Non-Executive Directors 

CAMBRIDGE, UNITED KINGDOM, 13 FEBRUARY 2023 – Cydar Medical (“Cydar” or “the Company”) a  global, cloud-based surgical software company, announces it has successfully completed a $11.5 million (£9.3 million) Series A funding round including a $3.7 million (£3 million) cornerstone investment by Pembroke  Venture Capital Trust (“VCT”). Proceeds will enable the Company to advance its pioneering artificial  intelligence (“AI”) surgical maps platform and also bolster the Company’s ongoing commercial expansion. 

Founded in 2012, Cydar Medical uses cutting-edge AI technology to transform the way information is provided  to clinicians undertaking image-guided minimally invasive surgery (“MIS”) simplifying complexities within operating theatres. The Company’s first product, Cydar EV Maps, is being used at leading hospitals across  the globe to optimise endovascular MIS procedures. The product creates a patient specific 3D map of soft  tissue, providing an integrated solution for procedure planning, intra-operative navigation and post-procedure  review. The AI and automation of processes within the novel software have been shown to increase clinician  confidence and reduce procedure times, reduce radiation exposure for patients and the clinical team and improve clinical workflow efficiencies^1-3. As the AI learns from surgical procedures it can help better inform clinical decision-making and future care. Cydar EV Maps is a certified Software-as-a-Medical Device (with an  EU/UK CE mark and US Food and Drug Administration (“FDA”) 510(k) clearance) and is generating growing  revenues for the Company. 

This Series A funding round will support the expansion of the Company’s Operations, Science and Development, Business Development and Customer Onboarding & Service teams. These expanded  capabilities will support the successful execution of the key strategic collaborations announced by the  Company last year with leading industry players, including Medtronic Vascular Inc. and BrainLab AG. The  proceeds will also enable the ongoing development of Cydar EV Maps. That includes the planned release of  the first version of Cydar EV Intelligent Maps in H1 2023, which will enable clinicians planning their MIS (minimally invasive surgery) cases to compare patient anatomy with prior cases undertaken globally and will, over time, provide predictive procedure planning capabilities. The goal is to allow patients, regardless of geographical location, to benefit from access to the experience of the world’s leading clinicians globally. The  Company also plans to release a generally applicable Cydar Maps product offering a solution for MIS  procedures beyond the current endovascular indication.  

The Series A financing was led by Pembroke VCT, managed by Pembroke Investment Managers LLP, who  focus on growth stage companies across a range of sectors. Pembroke VCT were joined in the round by existing shareholders, as well as a number of new investors which included Downing LLP, through its Downing  Healthcare Ventures fund, which focuses on investment in healthcare and life science companies based in the  UK. As part of the funding round, Andrew Wolfson, Chief Executive Officer of Pembroke Investment Managers  LLP and Dr Nigel Pitchford, Head of Healthcare Ventures at Downing LLP, have joined Cydar Medical’s Board  of Directors as Non-Executive Directors. They each bring over 25 years of experience in supporting the  successful growth of portfolio companies through venture capital funding. Dr Pitchford has also focused  specifically on healthcare ventures at a range of firms including Imperial Innovations, 3i Group and DFJ Esprit. 

Paul Mussenden, Chief Executive Officer of Cydar Medical commented:  

“We are pleased to have closed this Series A funding round backed by Pembroke VCT and Downing  Healthcare Ventures EIS. We are also appreciative of the significant continued support from our existing  shareholders and warmly welcome our new investors on Cydar Medical’s exciting journey. We are focused on improving patient outcomes by providing an integrated solution of pre-operative planning, intra-operative navigation and post-operative review for a range of procedures, using the power of AI to better inform care  decisions. This latest funding round will enable us to accelerate our vision of using AI to bring novel integrated  solutions to every step of the patient journey in image guided MIS. Feedback from our clinicians illustrates that  these capabilities increase their confidence at every stage of the patient pathway. 

“Over the past year we have made excellent operational progress having released significant new product functionality, enrolled the first patients in the ARIA⁴randomised controlled clinical study to demonstrate the  clinical and cost effectiveness benefits of the use of Cydar EV Maps and agreed the installation of the product  at over 50 new centres across the UK, US and EU, in part supported by establishing a number of important  collaborations with world leading industry players. Cydar Medical is at a key inflection point and we are working to leverage our novel world-class platform and capabilities to rapidly scale our intelligent surgical maps offering through increasing the number of end-users and launching additional value-add capabilities on the platform.  We look forward to executing on our strategy and progressing towards our vision of using Cydar’s technology  platform to create an ecosystem of products, tools and services to improve delivery of healthcare to enable a  world where all surgery conducted works exactly as planned.” 

– ENDS – 

For further information, please visit www.cydarmedical.com or contact: 

Cydar Medical 

Paul Mussenden, Chief Executive Officer [email protected] Cynthia Azucena, Global Marketing Director 

Emma Deanfield, Head of Investor Relations & Fundraising 

FTI Consulting +44 (0)20 3727 1000 Ben Atwell / Alex Davis [email protected] 

About Cydar Medical 

Cydar Medical is a global cloud-based software company that provides an integrated solution for planning,  navigation and review of surgical procedures using the power of artificial intelligence (“AI”) to augment a  clinician’s decision making. Its Cydar EV Maps product harnesses the latest in cloud graphics processing unit  (“GPU”) computing, computer vision and machine learning technology to advance surgical visualisation and  decision-making in theatre, and across the surgical pathway. The Company’s AI will continuously learn from 

procedures conducted globally to provide predictive analytics to assist clinicians in the operating room,  enabling them to make faster, easier and safer decisions in the future. The platform will deliver new products  and capabilities to improve the delivery of healthcare. Cydar Medical is headquartered in Cambridge, United  Kingdom, and is working towards its vision of a world where all surgery conducted works exactly as planned. 

For further information, please visit www.cydarmedical.com 

References and Notes 

¹ Shortell C, Veith Symposium New York, 2017 

² Southerland et al. Image-Based Three-Dimensional Fusion Computed Tomography Decreases Radiation  Exposure, Fluoroscopy Time, and Procedure Time During Endovascular Aortic Aneurysm Repair. Journal of  Vascular Surgery Abstracts e61. Volume 67, Number 6

³ Blandine et al. A prospective observational trial of fusion imaging in infrarenal aneurysms J Vasc Surg. 2018  Dec;68(6):1706-1713.e1. doi: 10.1016/j.jvs.2018.04.015. Epub 2018 May 24. 

⁴ ARtificially Intelligent image fusion system in comparison to standard treatment to guide endovascular Aortic  aneurysm repair (“ARIA”)